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. 2005 Aug 25;568(Pt 3):1047–1056. doi: 10.1113/jphysiol.2005.095372

Figure 1. Schematic drawing of the general experimental protocol.

Figure 1

Numbers on left side refer to microdialysis sites. Site 1 served as a control and received a dose of substance P with Ringer solution only. Site 2 received substance P in the presence of l-NAME to inhibit NO synthase. Site 3 received substance P in the presence of pyrilamine to antagonize H1 histamine receptors. Site 4 received substance P in the presence of l-NAME plus pyrilamine. Concentrations of substance P used were 10 and 20 μm infused for 15 min at a rate of 4 μl min−1. NO, nitric oxide; l-NAME, NG-nitro-l-arginine methyl ester; SNP, sodium nitroprusside.