Table 2.
Effects of altering ion conductances on motoneurone properties in a five-compartment motoneurone model of Dai et al. (2002)
| Condition 1 | Condition 2 | ||||
|---|---|---|---|---|---|
| Property | Slow Mn | Fast Mn | Slow Mn | Fast Mn | Agreement with data |
| Rheobase (nA) | +3 | +3 | +3 | +3 | A |
| Input resistance (MΩ) | 0 | 0 | 0 | 0 | A |
| Spike amplitude (mV) | −14.1 | −7.1 | −3.2 | −2.6 | B |
| AHP width (ms) | 0 | 0 | 0 | reduced | B |
| AHP amplitude (mV) | −1.8 | +0.4 | −1.4 | −0.4 | B |
| Spike threshold (mV) | +3.2 | +4.0 | +2.2 | +2.4 | A |
| f–I relationship shift | right | right | right | right | A |
Condition 1, reducing initial segment sodium conductance (gNa) by 25% and soma gNa by 15%. Condition 2, increasing initial segment delayed rectifier potassium conductance (gKdr) by 55% and soma gKdr by 42%. In right-hand column, A indicates very strong agreement, B indicates somewhat in agreement (see Table 1).