Table 2.

Values of the variables that were adjusted to fit the experimental data

Simulation object	Initial release probability per vesicle α1	Initial readily releasable pool size nT	Initial release probability P1	Decay constant of CaXF τF (s)
Pyramidal cells
Paired-pulse ratio vs interval	0.055	4.8	0.24	0.12
Five-pulse ratio versus frequency	0.055	4.8	0.24	0.16
Steady-state EPSC versus frequency	0.055	4.8	0.24	0.60
Facilitation interneurones
Paired-pulse ratio vs interval	0.060	7.5	0.37	0.12
Five-pulse ratio vs frequency	0.060	7.5	0.37	0.16
Steady-state EPSC vs frequency	0.060	7.5	0.37	0.60
Depression interneurones
Paired-pulse ratio vs interval	0.090	10.0	0.61	0.12
Five-pulse ratio vs frequency	0.090	10.0	0.61	0.16
Steady-state EPSC vs frequency	0.090	10.0	0.61	0.60

The initial release probability P₁ was not an independent variable but was calculated from the values of α₁ and n_T (eqn (2) in Methods).