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. 2005 Sep 1;569(Pt 1):315–323. doi: 10.1113/jphysiol.2005.092155

Figure 3. Effects and time course of the effects of lorazepam and diazepam on homonymous short-latency afferent inhibition (SAI).

Figure 3

Bar graphs show grand means across N20 +4 ms and N20 +6 ms interstimulus intervals at baseline and 1.5 (diazepam) or 2 (lorazepam), and 6 and 24 h after diazepam and lorazepam administration. Error bars are standard deviations. SAI is expressed by the amplitude of the conditioned MEP normalised to the unconditioned test MEP (y-axis). A repeated measures ANOVA with DRUG (diazepam versus lorazepam) and TIME (4 time points) as main within-subject factors shows a significant interaction between DRUG and TIME (F3,10= 5.15, P < 0.05). At the first interval after drug intake the amount of inhibition is significantly increased by diazepam (*P < 0.05) while it is reduced by lorazepam (*P < 0.05). In addition, there is significantly less SAI after lorazepam than after diazepam at this time point (*P < 0.05). The mean N20 latency was 18 ± 0.6 ms.