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. 2005 Sep 15;569(Pt 1):195–208. doi: 10.1113/jphysiol.2005.095943

Figure 8. Effects of myosin II fragments on neurotransmitter release.

Figure 8

Myosin II heavy chain fragments, MIIAF or MIIBF, were injected into presynaptic neurones at time 0, at a concentration in the injection pipette of 94 μm. Presynaptic neurones were stimulated at 0.05 Hz. A shows EPSPs from one representative experiment (a) and the first order derivative representing the rate of rise and fall for EPSPs (b). Black line represents control before injection; blue line is at 55 min after injection. The myosin IIB fragment, MIIBF was injected. B, normalized EPSP amplitudes are averaged. The resultant values are smoothed with a moving average algorithm and plotted against recording time. MIIAF (○, n = 5) or MIIBF (•, n = 4) were injected. C, bar graph illustrating the decrease in EPSP amplitude at 55 min after injection of MIIAF and MIIBF (*P < 0.01, Student's unpaired t test, MIIBF versus MIIAF).