Clonal analysis of growth arrest. (A) Relative CE
of the four fibroblast cultures at 33.5°C after 0 days (open bars), 3
days (▨), 7 days (cross-hatched bars), 10 days
(▧), and 14 days (solid bars) at 39.5°C. Results are means
of duplicate determinations (variance of replicate CE < ± 10%).
(B) Relative colony-forming efficiency at 33.5°C of
the endothelial culture HMME7 after 0 days (open bars), 3 days
(▨), 6 days (cross-hatched bars), and 9 days (▧)
at 36.5°C and at 39.5°C, respectively. Results are means ± SD
(n = 4). The corresponding numbers of SA
β-galactosidase positive cells were 5% (day 0), 11% (day 3), 54%
(day 6), and 79% (day 9) in cultures at 36.5°C, compared with 3%
(day 3), 6% (day 6), and 12% (day 9) in cultures at 39.5°C.