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. 2005 Sep 22;569(Pt 2):501–517. doi: 10.1113/jphysiol.2005.091918

Figure 10. Δ9-THC desensitizes CB1 receptors.

Figure 10

A, comparison of inhibition by WIN 55212-2 of EPSCs in control and Δ9-THC-treated neurones (450 nm for 19 h, followed by ≥ 20 min washout). B, comparison of DSE in control and Δ9-THC-treated neurones (as in A). C, sample time course of EPSCs in response to treatment with Δ9-THC alone (450 nm) and in combination with HU-210 (100 nm). D, sample time course of EPSCs in response to treatment with HU-210 in Δ9-THC-treated neurones (450 nm for 19 h, ≥ 20 min washout). E, summary of treatments with HU-210 in the presence of Δ9-THC and HU-210 in Δ9-THC-desensitized neurones. *P < 0.05, **P < 0.005 by Student's t test.