Table 1.

Biophysical parameters for activation and fast inactivation

	Voltage dependence of activation			Voltage dependence of fast inactivation			Recovery from fast inactivation
	V½ (mV)	k (mV)	n	V½ (mV)	k (mV)	n	τ1 (ms)¶	τ2 (ms)¶	n
WT-SCN1A	−19.4 ± 1.4	7.9 ± 0.2	13	−62.7 ± 1.7	−6.9 ± 0.2	14	2.4 ± 0.3 [85 ± 1%]	41 ± 6 [15 ± 1%]	14
P1632S	−27.3 ± 1.0‡	8.7 ± 0.2*	10	−84.7 ± 1.5§	−7.1 ± 0.3	9	2.7 ± 0.2 [82 ± 1%]	45 ± 5 [18 ± 1%]	8
V1611F	−27.9 ± 1.2‡	7.5 ± 0.2	11	−69.5 ± 0.9*	−6.8 ± 0.2	11	1.8 ± 0.2 [80 ± 2%*]	32 ± 5 [20 ± 1%*]	10
F1808L	−25.3 ± 1.3*	9.2 ± 0.2‡	12	−77.1 ± 1.3§	−7.9 ± 0.2†	11	2.5 ± 0.2 [69 ± 4%‡]	32 ± 5 [31 ± 4%‡]	11
T808S	−21.7 ± 1.3	8.3 ± 0.2	11	−66.5 ± 1.6	−6.9 ± 0.3	10	3.8 ± 0.3†[89 ± 1%]	63 ± 7*[11 ± 1%]	9
N1011I	−20.5 ± 1.9	8.1 ± 0.2	6	−70.1 ± 0.4*	−7.3 ± 0.4	6	3.4 ± 0.3*[85 ± 2%]	58 ± 6 [14 ± 3%]	6
V983A	−13.9 ± 1.1*	8.2 ± 0.3	8	−79.3 ± 1.5§	−7.1 ± 0.2	9	5.4 ± 0.5§[83 ± 3%]	37 ± 4 [16 ± 3%]	8

Values statistically significantly different from WT-SCN1A are indicated as follows:

^*P < 0.05;

^†P < 0.005;

^‡P < 0.0005;

^§P < 0.0001.

^¶values in square brackets are amplitude