Table 3.

Predicted influence of biophysical properties on net channel activity

Biophysical property	P1632S	F1808L	V1611F	T808S	N1011I	V983A
Peak current density	↑	↓	—	↑	↓	↓
Activation V½	↑	↑	↑	—	—	↓
Persistent INa	↑	↑	↑	—	—	—
Inactivation V½	↓	↓	↓	—	↓	↓
Recovery from inactivation	—	↓	↓	↓	↓	↓
Slow inactivation	↓/↑	—/↓	—/↓	↓/↑	↓/↑	↑

↑, predicted gain of channel activity;↓, predicted loss of channel activity; —, no predicted change in channel activity; ↓/↑, uncertain or mixed effects.