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. 2005 Oct 20;569(Pt 3):751–760. doi: 10.1113/jphysiol.2005.097477

Figure 5. Blockade of cannabinoid uptake modulates spiking activity in SON magnocellular neurones.

Figure 5

A, bath application of the cannabinoid transporter blocker OMDM-2 (5 μm) abolished the spiking activity induced in a SON neurone by DC injection (9 pA) and high-osmolarity aCSF (340 mosmol l−1). The spiking activity recovered after ∼30 min of washout of the OMDM-2. B, average changes in the mean firing frequency of SON neurones caused by the cannabinoid transporter blockers OMDM-2 (5 μm; n = 13) and AM404 (1–2 μm, n = 7). *P < 0.05.