Table 2.
The effects of piroxicam treatment on the interval between symphysis separation and birth and on the activity of PGHS1 and PGHS2
| Parameter | Vehicle | Piroxicam | P |
|---|---|---|---|
| Days between symphysis separation and birth | 8.5 ± 0.34 (6) | 10.8 ± 0.95 (6) | 0.043* |
| PGHS1 activity (ng TXB2 ml−1 (10 min)−1) | 211.33 ± 50.49 (3) | 36.22 ± 18.77 (4) | 0.014* |
| PGHS2 activity (ng PGE2 ml−1 (24 h)−1) | 4.489 ± 1.02 (4) | 3.67 ± 0.65 (4) | 0.522 |
Values are means ± s.e.m., with number of animals shown in parentheses. Guinea pigs were treated with vehicle (canola oil : DMSO 3 : 1) or piroxicam (5 mg kg−1 day−1) s.c. from the first day of pubic symphysis separation until delivery.
*
Significant difference calculated by the two-tailed t test.