Figure 10. Blockade of VEGF-induced elevation of L_pA/V_i by VEGF-R2 inhibition.

Populations of glomeruli were exposed for 60 min to control solution (open bar), 1 nm VEGF alone (filled bar), 1 nm VEGF plus the pan-VEGF receptor inhibitor (100 nm PTK787/ZK222584) (loosely cross-hatched bar), or 1 nm VEGF plus the selective VEGF-R2 inhibitor (10 nm ZM323881) (tightly cross-hatched bar). ^⋆⋆⋆P < 0.001, one-way ANOVA with Bonferroni correction.