Arterial (A), venous (B) and calculated arterio-venous differences (C) in plasma [Na+] differences, under Con (•) and Alk (▿) conditions. *Different from rest (P < 0.05, time main effect). †Alk > Con (P < 0.05, treatment main effect). ‡Alk tended to be > Con (P= 0.066, Cohen's d= 0.46, treatment main effect). Sample size and data presentation as in Fig. 3. Arterio-venous [Na+] differences are corrected for the a–v decline in plasma volume.