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. 2005 Nov 10;570(Pt 2):375–384. doi: 10.1113/jphysiol.2005.100115

Figure 5. Hypoxia and adenosine-related coronary artery dilatation.

Figure 5

A, adenosine concentration–response experiments in porcine coronary arteries with ITU, EHNA and NBTI in the organ bath. Vasodilatation was more pronounced during hypoxia (n = 9) than during normoxia (n = 9, P < 0.001). B, the effect of the non-xanthine A2A receptor antagonist, ZM241385 on hypoxia-induced vasodilatation. During 60 min of hypoxia ZM241385 (n = 5) attenuated hypoxia-induced vasodilatation compared to experiments without this antagonist (n = 5) or experiments with the selective A2B receptor antagonist MRS1754 (n = 4) (ANOVA, P < 0.001). In all experiments ITU, EHNA and NBTI were added to the organ bath.