Table 1.

Summary of analyses of NX^c/−p53^−/− medulloblastoma

Tumors containing 13;6 translocations are highlighted in green. Number of metaphases containing recurrent translocation are shown unbolded in parentheses. ND, not determined.

*Cyclin D2 (D2) and N-myc total RNA levels expressed as compared with P4 brain determined by Northern blot analyses (Fig. 9B). Yes, denotes expression; No, no expression detected. Overexpression of CyclinD2 is detected in the majority of the medulloblatomas.

^†CA, complex chromosomal amplications; Dmin, double minutes.

^‡Specific heterozygous loss of Ptc detected in NXcP25 by CGH (data not shown).

^§By SKY and single-chromosome paints, these tumors have 13;6 translocations, two copies of chromosome 6 (e.g., NXcP60 and NXcP142, Fig. 3A) and one copy of chromosome 13. NXcP172, with t(13;6;8) has one copy of chromosome 13 in all metaphases analyzed and metaphases containing one or two copies of chromosome 6.

^¶Loss of patched (Ptc) on chromosome 13 detected by FISH (see Fig. 4).

^‖Additional t(13;12;13) complex translocations were also observed in NXcP81, shown in Fig. 3A.

**NXcP155, 1 metaphase exhibited both N-myc CA and Dmins (1/20).