Skip to main content
. Author manuscript; available in PMC: 2006 May 22.
Published in final edited form as: Blood. 2005 Jan 6;105(8):3222–3229. doi: 10.1182/blood-2004-11-4205

Figure 5.

Figure 5

IgE- and IgE+Ag-induced mast cell migration can be divided into the early phase of Lyn/Syk-dependent release of soluble factors and the later PI3Kγ-dependent phase. (A) PI3Kγ−/− BMMCs were defective in migration in responses to SPE-7 IgE, IgE+Ag, or adenosine. (B) Fc∈;RIα−/− cells in upper wells were incubated with lower wells containing wild-type, lyn−/−, or syk−/− cells in the presence of SPE-7 or SCF. (C) Wild-type, lyn−/−, or syk−/− cells in upper wells were incubated with lower wells containing 206 IgE–sensitized wild-type cells in the presence of DNP-HSA or SCF. Mean values ± SD are shown from 2 (A) or 3 (B,C) independent experiments.