Figure 10. The predicted synaptic currents in response to a 0.1 ms pulse of 1 mm ACh (line at top) for wild-type (continuous line) and εL78P receptors (dotted line).

The currents were calculated from the estimates of the microscopic rate constants obtained from maximum likelihood fitting of Scheme 3; the values are shown in Table 5. The macroscopic decay after removal of ACh is dominated by a single exponential component with a time constant of 2.6 ms for the wild-type receptors and 26.7 ms for the εL78P receptors. The amplitude of the current is that for a single channel.