Table 1.
Potency (EC50) and Hill coefficient (h) determined from concentration–response relationships for GABA-, muscimol- and taurine-evoked currents in dissociated intracardiac neurones from neonatal (P2–5) and adult (P45–49) rats
| Agonist | Neonatal | Adult |
|---|---|---|
| GABA | ||
| EC50 (μm) | 30.1 ± 0.9 | ND |
| h | 1.3 ± 0.2 | ND |
| Muscimol | ||
| EC50 (μm) | 28.1 ± 1.2 | 33.6 ± 1.2 |
| h | 1.3 ± 0.1 | 1.3 ± 0.1 |
| Taurine | ||
| EC50 (mm) | 162 ± 46 | 195 ± 55 |
| h | 1.0 ± 0.1 | 1.0 ± 0.1 |
Data expressed as mean ± s.e.m., n = 5–6 cells per age group and agonist. Membrane potential, −60 mV. ND, not determined.