Figure 2. Autoradiographs showing the distribution of expression of OB-Rb mRNA (A and B) and MC3R mRNA (C and D) in the hypothalamus of the sheep fetus at 140 ± 1 d gestation. OB-Rb and MC3R mRNA was expressed predominately in the arcuate nucleus (ARC) and ventromedial hypothalmaus (VMH) in both saline infused (left panel) and glucose infused (right panel) fetuses. The expression of OB-Rb mRNA was higher in the VMH compared to the ARC in both saline infused and glucose infused fetuses. E, different letters denote significant differences between mRNA expression of OB-Rb in the VMN and ARC. Scale bar, 1.3 mm.