Figure 2. The effect of 2-APB on Ca²⁺ oscillations and STICs.

A, the upper record shows Ca²⁺ oscillations imaged in the perinuclear region of the cell, while the lower record shows the spontaneous transient inward currents (STICs) resulting from the intracellular increases in Ca²⁺. Addition of 100 μm 2-aminoethoxydiphenyl borate (2-APB) had the effect of almost abolishing the STICS, but the underlying Ca²⁺ oscillations, while reduced in amplitude, retained their normal rhythm and returned to control amplitude after washout of the drug. The summarized results (B and C) show essentially the same pattern as the original record in A.