Table 1.
Gating parameters for NaV1.4 constructs
| Activation | Fast inactivation | Slow inactivation | |||||
|---|---|---|---|---|---|---|---|
| V1/2 (mV) | k (mV) | V1/2 (mV) | k (mV) | V1/2 (mV) | k (mV) | I0 | |
| WT | −27.1 ± 1.2 | 6.0 ± 0.2 | −71.8 ± 0.9 | 4.5 ± 0.1 | −55.0 ± 2.2 | 12.7 ± 0.8 | 0.17 ± 0.019 |
| (15) | (15) | (5) | |||||
| T323M | −25.8 ± 1.2 | 5.9 ± 0.2 | −70.7 ± 0.8 | 4.3 ± 0.1 | −60.4 ± 1.4* | 13.3 ± 0.5 | 0.16 ± 0.008 |
| (15) | (15) | (7) | |||||
| F1705I | −27.9 ± 0.7 | 5.8 ± 0.1 | − 63.2 ± 0.8** | 4.5 ± 0.1 | − 51.9 ± 0.9 | 9.9 ± 0.6* | 0.20 ± 0.011 |
| (20) | (5) | ||||||
Values are means +s.e.m. with number of experiments in parenthesis
*
Significantly different from WT, P < 0.05;
**
significantly different from WT, P < 0.001.