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. 2005 Apr 7;565(Pt 3):965–980. doi: 10.1113/jphysiol.2005.084657

Figure 8. Effects of cholinergic antagonists on carbachol-induced GG motor suppression.

Figure 8

Group data showing the effects of pre-application of cholinergic antagonists into the HMN on GG muscle suppression produced by 100 μm carbachol (Carb, see left bar on graph). Pre-application of 10 μm atropine significantly reduced this carbachol-induced GG muscle suppression (Atr + Carb) indicating a contribution of mAChRs. In contrast, pre-application of the nAChR antagonist mecamylamine (10 μm) did not significantly affect this carbachol-induced GG suppression (Mec + Carb). Combined administration of atropine and mecamylamine (Atr + Mec + Carb) also reduced GG suppression compared with when carbachol was applied alone, consistent with mAChR-induced GG suppression. However, pre-application of DβE (100 μm) increased the magnitude of the carbachol-induced GG suppression (DβE + Carb). See text for further details. *Significant difference compared with application of carbachol alone (Carb).