Table 4.
Cardiac magnetic resonance imaging of WT and CK−/− mice
| WT | CK−/− | |||
|---|---|---|---|---|
| Anatomy and basal contractility | (n=7) | (n=9) | ||
| Mean LV mass (mg) | 130.6±8.3 | 163.2 ±3.6* | ||
| Mean LV mass BW (mg g−1) | 3.39±0.17 | 4.35±0.12** | ||
| End Diastolic LV thickness (mm) | 1.33 ±0.05 | 1.32±0.06 | ||
| Systolic LV thickness (mm) | 2.45±0.06 | 2.43±0.09 | ||
| Stroke volume (μ l) | 27.1±2.7 | 31.6±3.1 | ||
| Cardiac output (ml min−1) | 16.7±2.0 | 21.6±2.4 | ||
| Heart rate (beats min−1) | 611±30 | 683±7 | ||
| Ejection fraction | 0.90±0.02 | 0.90±0.02 | ||
| Vmax ejection (mm2 ms−1) | − 0.35±0.02 | −0.37±0.04 | ||
| Vmax filling (mm2 ms−1) | 0.29±0.03 | 0.31±0.02 | ||
| Contractility under dobutamine− | ||||
| induced stress | (n=5) | (n=7) | ||
| Heart rate (beats min−1) | 637±23 | 688±10 | ||
| Ejection fraction | 0.96±0.01† | 0.95±0.01† | ||
| Vmax ejection (mm2 ms−1) | − 0.47±0.03† | −0.52±0.05 † | ||
| Vmax filling (mm2 ms−1) | 0.29±0.03 | 0.34±0.02 | ||
†
Dobutamine versus control.
*
deficient versus WT. Dobutamine infusion, 1.7 mg kg−1, i.p. BW, body weight; LV, left ventricle.