Table 2.

Spontaneous baroreflex sensitivity (ΔHR/ΔMAP) in wild-type and Cry1^−/−Cry2^−/− mice

		Day			Night
	Mouse no.	ΔHR/ΔMAP	R2	Number of data (×104)	ΔHR/ΔMAP	R2	Number of data (×104)
Wild-type
	1	−9.0	0.29	12.1	−14.4	0.28	5.7
	2	−11.7	0.32	14.0	−16.3	0.33	4.4
	3	−10.6	0.33	10.1	−14.5	0.25	3.5
	4	−6.7	0.31	13.3	−10.6	0.30	5.3
	5	−9.8	0.39	14.4	−12.8	0.33	6.1
	6	−10.3	0.41	11.9	−13.1	0.35	9.3
	Mean ± s.e.m.	−9.7 ± 0.7		12.6 ± 0.6	−13.6 ± 0.8***		5.7 ± 0.8***
Cry1−/−Cry2−/−
	1	−28.6	0.36	4.6	−26.8	0.26	4.2
	2	−25.1	0.32	8.9	−22.4	0.27	8.5
	3	−15.9	0.33	7.1	−16.7	0.30	7.6
	4	−22.3	0.23	8.6	−21.5	0.24	6.8
	5	−23.6	0.24	8.7	−22.2	0.21	8.3
	Mean ± s.e.m.	−23.1 ± 2.1***		7.6 ± 0.8***	−21.9 ± 1.6***		7.1 ± 0.8***

ΔHR/ΔMAP, heart rate response to the spontaneous change in mean arterial pressure (beats min⁻¹ mmHg⁻¹). Number of data, the number meeting the criteria for inclusion in spontaneous baroreflex analyses. Total number of data during the day or night was 43.2 × 10⁴. R², square of correlation coefficient; ΔHR was highly correlated with ΔMAP in all mice at the level of P < 0.00001.

^***Significant differences from wild-type mice during the day, P < 0.001.