Figure 3. BK response in isolated jugular capsaicin-sensitive neurones in gramicidin-perforated patch-clamp recordings.

A, BK and muscimol (selective GABA_A receptor agonist) evoked membrane depolarization and action potential discharge in current-clamp mode. B, BK (1 μm, for 30 s) produced a large inward current in airway labelled capsaicin-sensitive neurones (representative of 12 neurones). C, rapid reversal of the BK-induced current by NFA (100 μm for 15 s) applied 15 s after BK (1 μm, for 30 s) application (representative of 5 neurones).