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. 2005 Apr 21;566(Pt 1):143–160. doi: 10.1113/jphysiol.2005.086595

Figure 8. Ih activity contributes to the expression of RSE.

Figure 8

A, effect of 30 μm ZD7288, an Ih channel blocker, on STP under basal conditions. Aa, the time course of changes in fEPSP1 slopes following ZD7288 perfusion. Representative recordings at time −20 and 20 are shown in the inset. Ab, the STP ratio of 10 successive fEPSPs, which were normalized to each fEPSP1. B, effect of 30 μm ZD7288 on STP after LTP induction. Ba, the time course of changes in fEPSPs slopes following ZD7288 perfusion 30 min after tetanus (100 Hz, 100 pulses). Bb, the STP ratio was reduced after LTP induction, and no additional decrease in STP ratios was induced by application of ZD7288, that is, the effects of LTP and ZD7288 on STP were occlusive. C, comparisons of the effects of ZD7288 and Cs+ before and after various synaptic experiences. The same protocol as shown in panel B was used. ZD7288 and Cs+ became ineffective at synapses that experienced LTP and depotentiation, but not LTD or strong LTP. *P < 0.05, **P < 0.01 versus control; Tukey's test (n = 5–7 slices).