Table 1.
Heart rate (HR) and arterial blood pressure responses
| Rest | EX90 | EX120 | EX150 | ||
|---|---|---|---|---|---|
| HR | Control (bpm) | 62 ± 4 | 88 ± 4* | 114 ± 2*† | 142 ± 1*†‡ |
| Metoprolol (bpm) | 55 ± 4# | 80 ± 2*# | 102 ± 2*†# | 124 ± 3*†‡# | |
| Glycopyrrolate (bpm) | 101 ± 2#$ | 114 ± 3*#$ | 135 ± 3*†#$ | 154 ± 2*†‡#$ | |
| MAP | Control (mmHg) | 89 ± 2 | 91 ± 3 | 95 ± 3 | 115 ± 5*†‡ |
| Metoprolol (mmHg) | 84 ± 2# | 91 ± 3* | 96 ± 4* | 109 ± 6*†‡# | |
| Glycopyrrolate (mmHg) | 91 ± 2$ | 87 ± 3 | 92 ± 3 | 105 ± 4*†‡# | |
| SBP | Control (mmHg) | 122 ± 3 | 133 ± 6* | 149 ± 5*† | 170 ± 8*†‡ |
| Metoprolol (mmHg) | 118 ± 3 | 130 ± 5* | 143 ± 6*† | 165 ± 9*†‡ | |
| Glycopyrrolate (mmHg) | 124 ± 3 | 125 ± 4 | 131 ± 5#$ | 150 ± 6*†‡#$ | |
| DBP | Control (mmHg) | 67 ± 2 | 68 ± 3 | 73 ± 2*† | 81 ± 4*†‡ |
| Metoprolol (mmHg) | 64 ± 2 | 68 ± 2 | 72 ± 3* | 79 ± 4*†‡ | |
| Glycopyrrolate (mmHg) | 74 ± 2#$ | 70 ± 2 | 68 ± 2*#$ | 75 ± 3‡#$ |
Values are means ± s.e.m.; bpm, beats min−1; MAP, mean arterial pressure; SBP, systolic blood pressure; DBP, diastolic blood pressure.
*
Different from rest, < 0.05;P
†
different from EX90, P < 0.05;
‡
different from EX120, P < 0.05;
#
different from control, P < 0.05;
$
different from metoprolol, P < 0.05.