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. 2005 May 26;566(Pt 3):907–919. doi: 10.1113/jphysiol.2005.089987

Figure 5. ChE influences cholinergic modulation of synaptic transmission in visual cortex slices.

Figure 5

A, concentration–response curve of ACh effects on FP amplitudes is shifted towards lower values in the presence of 1 μm edrophonium (0.5 μm, n = 4; 1 μm, n = 6; 10 μm, n = 5; 100 μm, n = 5; 500 μm, n = 5). B, in the presence of 10 μm edrophonium (Edro), a depression of FP amplitudes was observed at ACh concentrations ranging from 5–100 μm (5 μm, n = 10; 10 μm, n = 11; 100 μm, n = 5), while no changes were found at ACh concentrations ranging from 0.5–2 μm (0.5 μm, n = 5; 1 μm, n = 13; 2 μm, n = 9). Pirenzepine (pir; 2 μm) unmasked ACh-induced facilitation of FPs in the presence of 10 μm edrophonium (10 μm ACh, n = 8). Bath application of muscarine produced an effect similar to that observed with ACh in the presence of 10 μm edrophonium. In A and B, symbols represent the mean amplitude of FPs during the last 3 min of agonist application, normalized with respect to the mean amplitude of FPs during the last 3 min before drug application. s.e.m. is shown as a vertical bar for each symbol.