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. 2006 Feb 7;107(11):4338–4345. doi: 10.1182/blood-2005-12-5021

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Copyright © 2006, The American Society of Hematology

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Figure 2. — SHIP^–/– WBM and purified HSCs have compromised reconstituting activity. (A) CRU activity calculated based on the percentage of global repopulation in the PB by donor WBM cells (SHIP^–/– [▪] and WT []). (B) Percentage of global repopulation of PB by SHIP^–/– (▪) and WT () donor in a CRU assay. (C) Percentage of lymphoid and myeloid PB cells derived from SHIP^–/– (▪) or WT () WBM 16 weeks after transplantation in a CRU assay. (D) FACS plots show the level of PB reconstitution 16 weeks after KTLS transplantation in a representative DC assay mouse using sorted SHIP^–/– and WT KTLS cells. (E) Percentage of global reconstitution 16 weeks after transplantation of sorted KTLS (SHIP^–/– [▪] and WT []) (n = 11 over 2 different experiments). (F) Proportion of lymphoid and myeloid PB cells derived from SHIP^–/– (▪) or WT () WBM 16 weeks after KTLS transplantation. (G) Percentage of global reconstitution 12 weeks after sorted KFLS transplantation (SHIP^–/– [▪] and WT []) (n = 7). Significance was established using the unpaired student t test (Prism 4): **P < .001; *P < .01; ++P < .005; and +P < .05 (mean ± SEM).

Inline graphic — SHIP^–/– WBM and purified HSCs have compromised reconstituting activity. (A) CRU activity calculated based on the percentage of global repopulation in the PB by donor WBM cells (SHIP^–/– [▪] and WT []). (B) Percentage of global repopulation of PB by SHIP^–/– (▪) and WT () donor in a CRU assay. (C) Percentage of lymphoid and myeloid PB cells derived from SHIP^–/– (▪) or WT () WBM 16 weeks after transplantation in a CRU assay. (D) FACS plots show the level of PB reconstitution 16 weeks after KTLS transplantation in a representative DC assay mouse using sorted SHIP^–/– and WT KTLS cells. (E) Percentage of global reconstitution 16 weeks after transplantation of sorted KTLS (SHIP^–/– [▪] and WT []) (n = 11 over 2 different experiments). (F) Proportion of lymphoid and myeloid PB cells derived from SHIP^–/– (▪) or WT () WBM 16 weeks after KTLS transplantation. (G) Percentage of global reconstitution 12 weeks after sorted KFLS transplantation (SHIP^–/– [▪] and WT []) (n = 7). Significance was established using the unpaired student t test (Prism 4): **P < .001; *P < .01; ++P < .005; and +P < .05 (mean ± SEM).