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ICI 182,780 blocks the E2-mediated diminution of uterine sGC mRNA expression. Ovariectomized rats were treated with the pure ER antagonist, ICI 182,780, 30 min before the administration of E2 (40 μg/kg body weight). Animals were killed after 3 h, and sGC α1 and β1 mRNA levels were determined by real-time Q-PCR. Mean values ± SEM (Con, n = 6; E2, n = 9; E2 + ICI, n = 6; ICI, n = 8) were normalized to 36b4 and graphed as percent of control.
