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. 2001 Jan 2;98(2):729–734. doi: 10.1073/pnas.011370498

Figure 2.

Figure 2

Dominant negative effects of 61GA, 61GS, and 62GA on SUR2B + Kir 6.1 current expression. (A) Whole-cell current traces recorded from cells transiently transfected with SUR2B + Kir 6.1 (WT), SUR2B + Kir 6.1 + 61GA (61GA), SUR2B + Kir 6.1 + 61GS (61GS), or SUR2B + Kir 6.1 + 62GA (62GA) under the control conditions (5 min after breakin), in the presence of diazoxide (300 μM) and glibenclamide (10 μM), respectively. The pipette solution (see Methods) was supplemented with 0.5 mM GDP. (B) Summarized data for the currents measured at −100 mV. P < 0.01 one-way ANOVA.