Table 3.

Results of Clinical Trials Included for Review

	Weight (kg)		BMI (kg/m2)		Waist-Hip Ratio†
Source	Metformin	Placebo	Metformin	Placebo	Metformin	Placebo
Charles et al,12 2000	−0.50	0.10	—	—	−0.008	−0.015
Charles et al,13 1998	−2.0	−0.8	—	—	—	—
Fontbonne et al,14 1996	−2.0*	−0.8	—	—	−0.009*	−0.017
Guigliano et al,15 1993	—	—	0	0	0	0
Kantola et al,16 2002	−0.2	0.2	—	—	—	—
Lawson et al,17 1970	−3.6	−2.22	—	—	—	—
Lehtovorta et al,18 2001	−2.6	−1.2	—	—	—	—
More et al,l19 1999	−0.6	0.3	−0.3	0.2	0.01	0.05
Paolisso et al,20 1998	−2.8*	−0.25	−1.0	−0.5	0.2	0.25

* Indicates statistically significant (P <.05) difference from baseline.

† A change in ratios cannot be expressed in terms of units.