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. Author manuscript; available in PMC: 2006 May 24.
Published in final edited form as: J Comb Chem. 2004;6(3):437–442. doi: 10.1021/cc0340473

Figure 4.

Figure 4

Relative activity of library 1{2,13;1–24} against Plasmodium falciparum 3D7 in cultured human erythrocytes. Substituents for R1 are arrayed on the X-axis, broken into groups representing the general structural class of substituents. Substituents for R2 are shown on the Y-axis. Grayscale shade represents the percent of parasite growth at 30 nm drug concentration relative to untreated cultures. “−“ refers to cultures treated with no drug. “− −“ refers to cultures treated with 30 nM negative control compound 4-amino-7-chloroquinoline. “+” refers to cultures treated with 30 nM Chloroquine. The structures of two representative active compounds are shown above the graphic.