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. 2000 Apr;196(Pt 3):425–432. doi: 10.1046/j.1469-7580.2000.19630425.x

The spleen of the one humped camel (Camelus dromedarius) has a unique histological structure

MOHAMED ZIDAN 1 ,3 , ANWAR KASSEM 1 , ALI DOUGBAG 1 , EBTEHAG EL GHAZZAWI 2 , MOHAMED ABD EL AZIZ 1 , REINHARD PABST 3 ,✉
PMCID: PMC1468078  PMID: 10853964

Abstract

The histology and structure of 38 spleens of the dromedary (aged 0.5–15 y) were studied in relation to age. The spleen was found to have a thick capsule (292±106 mm) divided into an outer layer (113±39 mm) composed mainly of connective tissue and an inner layer (180±81 mm) consisting mainly of smooth muscle cells. Vascular and avascular trabeculae extend from the capsule, the former containing arteries and nerves but no trabecular veins, the latter being divided structurally into primary and secondary trabeculae. Subcapsular and peritrabecular blood sinuses around primary and vascular trabeculae are unique to the camel spleen. The central artery emerges from the periarterial lymphatic sheath and branches into up to 4 penicilli which extend as sheathed arterioles (42±8 μm). These are found near or surrounded by blood sinusoids of the red pulp. A wide marginal zone surrounds the white pulp and contains sheathed arteries but no marginal sinuses. The red pulp is characteristically divided into cords by secondary trabeculae and contains venous sinusoids of different sizes. The camel spleen is of a sinusal type that can store blood. The thick muscular capsule and trabeculae pump the stored blood according to the body's need. Both closed and open circulations are found. The venous return is unique as the blood flow is from the venous sinusoids of the red pulp to the peritrabecular sinuses to the subcapsular sinuses to the splenic vein. No significant structural differences related to age were found.

Keywords: White pulp, red pulp, marginal zone, periarterial macrophage sheath

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Selected References

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  1. Barnhart M. I., Baechler C. A., Lusher J. M. Arteriovenous shunts in the human spleen. Am J Hematol. 1976;1(1):105–114. doi: 10.1002/ajh.2830010112. [DOI] [PubMed] [Google Scholar]
  2. Blue J., Weiss L. Electron microscopy of the red pulp of the dog spleen including vascular arrangements, periarterial macrophage sheaths (ellipsoids), and the contractile, innervated reticular meshwork. Am J Anat. 1981 Jun;161(2):189–218. doi: 10.1002/aja.1001610205. [DOI] [PubMed] [Google Scholar]
  3. Blue J., Weiss L. Vascular pathways in nonsinusal red pulp--an electron microscope study of the cat spleen. Am J Anat. 1981 Jun;161(2):135–168. doi: 10.1002/aja.1001610203. [DOI] [PubMed] [Google Scholar]
  4. Burke J. S., Simon G. T. Electron microscopy of the spleen. I. Anatomy and microcirculation. Am J Pathol. 1970 Jan;58(1):127–155. [PMC free article] [PubMed] [Google Scholar]
  5. Chen L. T. Microcirculation of the spleen: and open or closed circulation? Science. 1978 Jul 14;201(4351):157–159. doi: 10.1126/science.663644. [DOI] [PubMed] [Google Scholar]
  6. Chen L. T., Weiss L. Electron microscopy of the red pulp of human spleen. Am J Anat. 1972 Aug;134(4):425–457. doi: 10.1002/aja.1001340404. [DOI] [PubMed] [Google Scholar]
  7. Chen L. T., Weiss L. The role of the sinus wall in the passage of erythrocytes through the spleen. Blood. 1973 Apr;41(4):529–537. [PubMed] [Google Scholar]
  8. Fujita T. A scanning electron microscope study of the human spleen. Arch Histol Jpn. 1974 Nov;37(3):187–216. doi: 10.1679/aohc1950.37.187. [DOI] [PubMed] [Google Scholar]
  9. Fukuta K., Nishida T., Mochizuki K. Electron microscopy of the splenic circulation in the chicken. Nihon Juigaku Zasshi. 1976 Jun;38(03):241–254. doi: 10.1292/jvms1939.38.241. [DOI] [PubMed] [Google Scholar]
  10. HEGAZI A. E. H. The spleen of the camel compared with other domesticated animals and its microscopic examination. J Am Vet Med Assoc. 1953 Mar;122(912):182–184. [PubMed] [Google Scholar]
  11. Irino S., Murakami T., Fujita T. Open circulation in the human spleen, Dissection scanning electron microscopy of conductive-stained tissue and observation of resin vascular casts. Arch Histol Jpn. 1977 Sep;40(4):297–304. doi: 10.1679/aohc1950.40.297. [DOI] [PubMed] [Google Scholar]
  12. Jacobsen G. Morphological-histochemical comparison of dog and cat splenic ellipsoid sheaths. Anat Rec. 1971 Jan;169(1):105–113. doi: 10.1002/ar.1091690110. [DOI] [PubMed] [Google Scholar]
  13. MOORE R. D., MUMAW V. R., SCHOENBERG M. D. THE STRUCTURE OF THE SPLEEN AND ITS FUNCTIONAL IMPLICATIONS. Exp Mol Pathol. 1964 Feb;33:31–50. doi: 10.1016/0014-4800(64)90016-4. [DOI] [PubMed] [Google Scholar]
  14. Murakami T., Fujita T., Miyoshi M. Closed circulation in the rat spleen as evidenced by scanning electron microscopy of vascular casts. Experientia. 1973 Nov 15;29(11):1374–1375. doi: 10.1007/BF01922828. [DOI] [PubMed] [Google Scholar]
  15. Ngeranwa J. J., Gathumbi P. K., Mutiga E. R., Agumbah G. J. Pathogenesis of Trypanosoma (brucei) evansi in small east African goats. Res Vet Sci. 1993 May;54(3):283–289. doi: 10.1016/0034-5288(93)90124-x. [DOI] [PubMed] [Google Scholar]
  16. SNOOK T. A comparative study of the vascular arrangements in mammalian spleens. Am J Anat. 1950 Jul;87(1):31–77. doi: 10.1002/aja.1000870103. [DOI] [PubMed] [Google Scholar]
  17. Satoh T., Takeda R., Oikawa H., Satodate R. Immunohistochemical and structural characteristics of the reticular framework of the white pulp and marginal zone in the human spleen. Anat Rec. 1997 Dec;249(4):486–494. doi: 10.1002/(SICI)1097-0185(199712)249:4<486::AID-AR8>3.0.CO;2-P. [DOI] [PubMed] [Google Scholar]
  18. Schnitzer B., Sodeman T., Mead M. L., Contacos P. G. Pitting function of the spleen in malaria: ultrastructural observations. Science. 1972 Jul 14;177(4044):175–177. doi: 10.1126/science.177.4044.175. [DOI] [PubMed] [Google Scholar]
  19. Seki A., Abe M. Scanning electron microscopic studies on the microvascular system of the spleen in the rat, cat, dog, pig, horse and cow. Nihon Juigaku Zasshi. 1985 Apr;47(2):237–249. doi: 10.1292/jvms1939.47.237. [DOI] [PubMed] [Google Scholar]
  20. Steiniger B., Barth P., Herbst B., Hartnell A., Crocker P. R. The species-specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone. Immunology. 1997 Oct;92(2):307–316. doi: 10.1046/j.1365-2567.1997.00328.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Tanaka H., Hataba Y., Saito S., Fukushima O., Miyasaka M. Phenotypic characteristics and significance of reticular meshwork surrounding splenic white pulp of mice. J Electron Microsc (Tokyo) 1996 Oct;45(5):407–416. doi: 10.1093/oxfordjournals.jmicro.a023459. [DOI] [PubMed] [Google Scholar]
  22. Timens W., Boes A., Rozeboom-Uiterwijk T., Poppema S. Immaturity of the human splenic marginal zone in infancy. Possible contribution to the deficient infant immune response. J Immunol. 1989 Nov 15;143(10):3200–3206. [PubMed] [Google Scholar]
  23. Ueda H., Abe M., Takehana K., Iwasa K., Hiraga T. Ultrastructure of the red pulp in spleen innervation in horse and pig. Acta Anat (Basel) 1991;141(2):151–158. doi: 10.1159/000147115. [DOI] [PubMed] [Google Scholar]
  24. WEISS L. THE WHITE PULP OF THE SPLEEN. THE RELATIONSHIPS OF ARTERIAL VESSELS, RETICULUM AND FREE CELLS IN THE PERIARTERIAL LYMPHATIC SHEATH. Bull Johns Hopkins Hosp. 1964 Aug;115:99–172. [PubMed] [Google Scholar]
  25. Westermann J., Willführ K. U., Pabst R. Influence of donor and host age on the regeneration and blood flow of splenic transplants. J Pediatr Surg. 1988 Sep;23(9):835–838. doi: 10.1016/s0022-3468(88)80234-3. [DOI] [PubMed] [Google Scholar]

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