Stimulation of RNase P activity by Hsp27. Stimulation by Hsp27 of human
nuclear RNase P activity was investigated by mixing 0.115 μg of
enzyme purified through a Mono Q column step with different amounts of
Hsp27 or 50 ng of BSA. The mixtures were incubated at 37°C
(●, Hsp27; ○, BSA) or 43°C
(■, Hsp27; □, BSA) for 30 min. After incubation
at room temperature for another 30 min, the RNase P activity was
assayed at 37°C for 10 min with the use of pSupS1 as substrate (see
Materials and Methods).