Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition of cyclin D/Cdk4 and cyclin A2/Cdk2 activity by p27Xic1. Purified cyclin D/Cdk4 or cyclin A2/Cdk2 complexes were preincubated with the indicated amounts of GST-p27Xic1 or GST alone (control), and the kinase reaction was performed with either the C-terminal half of human retinoblastoma protein (hRb) as substrate for Cdk4 or histone H1 for Cdk2, as described in Materials and Methods.
