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. 1997 Sep;105(9):994–997. doi: 10.1289/ehp.97105994

Factors associated with serum levels of estradiol and sex hormone-binding globulin among premenopausal Japanese women.

C Nagata 1, N Kaneda 1, M Kabuto 1, H Shimizu 1
PMCID: PMC1470357  PMID: 9300929

Abstract

We measured serum levels of estradiol (E(2)) and sex hormone-binding globulin (SHBG) among 50 healthy premenopausal Japanese women in 1994 in Gifu, Japan, to investigate the relationships between potential risk factors for breast cancer and hormone levels. Using a self-administered questionnaire, we collected data on body size, physical activity, and previous disease history, as well as menstrual and reproductive histories of the woman and her mother. Blood samples were drawn from each subject on the 11th and 22nd days of her menstrual cycle. Higher serum E(2) levels were observed for women with shorter menstrual cycles. Age as well as cycle length were included in the regression models to determine the associations between hormone levels and study variables. Body mass index (BMI) was inversely related to SHBG level measured at the 11th day of the cycle, after adjusting for age and cycle length (r = -0.33; p = 0. 03). Women born in spring/summer had higher levels of E(2) on the 22nd day (p = 0.07) and higher levels of SHBG on both the 11th and 22nd days of the cycle (p = 0.01 and p = 0.06, respectively) than those born in other seasons. Physical activity at 13-15 years of age was inversely related to E(2) level on the 11th day of the cycle after controlling for age, cycle length, BMI, and birth month (r = -0.35; p = 0.04).

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Selected References

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  1. Albanes D., Blair A., Taylor P. R. Physical activity and risk of cancer in the NHANES I population. Am J Public Health. 1989 Jun;79(6):744–750. doi: 10.2105/ajph.79.6.744. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anbazhagan R., Gusterson B. A. Reversed cerebral asymmetry and breast cancer. Lancet. 1992 Apr 25;339(8800):1056–1056. [PubMed] [Google Scholar]
  3. Apter D., Reinilä M., Vihko R. Some endocrine characteristics of early menarche, a risk factor for breast cancer, are preserved into adulthood. Int J Cancer. 1989 Nov 15;44(5):783–787. doi: 10.1002/ijc.2910440506. [DOI] [PubMed] [Google Scholar]
  4. Apter D., Vihko R. Early menarche, a risk factor for breast cancer, indicates early onset of ovulatory cycles. J Clin Endocrinol Metab. 1983 Jul;57(1):82–86. doi: 10.1210/jcem-57-1-82. [DOI] [PubMed] [Google Scholar]
  5. Beitins I. Z., McArthur J. W., Turnbull B. A., Skrinar G. S., Bullen B. A. Exercise induces two types of human luteal dysfunction: confirmation by urinary free progesterone. J Clin Endocrinol Metab. 1991 Jun;72(6):1350–1358. doi: 10.1210/jcem-72-6-1350. [DOI] [PubMed] [Google Scholar]
  6. Bennett I. C., McCaffrey J. F., McCaffrey E., Wyatt B. Serum oestradiol in women with and without breast disease. Br J Cancer. 1990 Jan;61(1):142–146. doi: 10.1038/bjc.1990.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bernstein L., Depue R. H., Ross R. K., Judd H. L., Pike M. C., Henderson B. E. Higher maternal levels of free estradiol in first compared to second pregnancy: early gestational differences. J Natl Cancer Inst. 1986 Jun;76(6):1035–1039. [PubMed] [Google Scholar]
  8. Bernstein L., Henderson B. E., Hanisch R., Sullivan-Halley J., Ross R. K. Physical exercise and reduced risk of breast cancer in young women. J Natl Cancer Inst. 1994 Sep 21;86(18):1403–1408. doi: 10.1093/jnci/86.18.1403. [DOI] [PubMed] [Google Scholar]
  9. Bernstein L., Pike M. C., Ross R. K., Henderson B. E. Age at menarche and estrogen concentrations of adult women. Cancer Causes Control. 1991 Jul;2(4):221–225. doi: 10.1007/BF00052137. [DOI] [PubMed] [Google Scholar]
  10. Bernstein L., Pike M. C., Ross R. K., Judd H. L., Brown J. B., Henderson B. E. Estrogen and sex hormone-binding globulin levels in nulliparous and parous women. J Natl Cancer Inst. 1985 Apr;74(4):741–745. [PubMed] [Google Scholar]
  11. Bernstein L., Ross R. K. Endogenous hormones and breast cancer risk. Epidemiol Rev. 1993;15(1):48–65. doi: 10.1093/oxfordjournals.epirev.a036116. [DOI] [PubMed] [Google Scholar]
  12. Bullen B. A., Skrinar G. S., Beitins I. Z., von Mering G., Turnbull B. A., McArthur J. W. Induction of menstrual disorders by strenuous exercise in untrained women. N Engl J Med. 1985 May 23;312(21):1349–1353. doi: 10.1056/NEJM198505233122103. [DOI] [PubMed] [Google Scholar]
  13. Ekbom A., Trichopoulos D., Adami H. O., Hsieh C. C., Lan S. J. Evidence of prenatal influences on breast cancer risk. Lancet. 1992 Oct 24;340(8826):1015–1018. doi: 10.1016/0140-6736(92)93019-j. [DOI] [PubMed] [Google Scholar]
  14. Fisher E. C., Nelson M. E., Frontera W. R., Turksoy R. N., Evans W. J. Bone mineral content and levels of gonadotropins and estrogens in amenorrheic running women. J Clin Endocrinol Metab. 1986 Jun;62(6):1232–1236. doi: 10.1210/jcem-62-6-1232. [DOI] [PubMed] [Google Scholar]
  15. Friedenreich C. M., Howe G. R., Miller A. B., Jain M. G. A cohort study of alcohol consumption and risk of breast cancer. Am J Epidemiol. 1993 Mar 1;137(5):512–520. doi: 10.1093/oxfordjournals.aje.a116704. [DOI] [PubMed] [Google Scholar]
  16. Ingram D. M., Nottage E. M., Willcox D. L., Roberts A. Oestrogen binding and risk factors for breast cancer. Br J Cancer. 1990 Feb;61(2):303–307. doi: 10.1038/bjc.1990.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Janerich D. T., Hayden C. L., Thompson W. D., Selenskas S. L., Mettlin C. Epidemiologic evidence of perinatal influence in the etiology of adult cancers. J Clin Epidemiol. 1989;42(2):151–157. doi: 10.1016/0895-4356(89)90088-7. [DOI] [PubMed] [Google Scholar]
  18. Langley M. S., Hammond G. L., Bardsley A., Sellwood R. A., Anderson D. C. Serum steroid binding proteins and the bioavailability of estradiol in relation to breast diseases. J Natl Cancer Inst. 1985 Nov;75(5):823–829. doi: 10.1093/jnci/75.5.823. [DOI] [PubMed] [Google Scholar]
  19. Loucks A. B., Mortola J. F., Girton L., Yen S. S. Alterations in the hypothalamic-pituitary-ovarian and the hypothalamic-pituitary-adrenal axes in athletic women. J Clin Endocrinol Metab. 1989 Feb;68(2):402–411. doi: 10.1210/jcem-68-2-402. [DOI] [PubMed] [Google Scholar]
  20. Mittendorf R., Longnecker M. P., Newcomb P. A., Dietz A. T., Greenberg E. R., Bogdan G. F., Clapp R. W., Willett W. C. Strenuous physical activity in young adulthood and risk of breast cancer (United States). Cancer Causes Control. 1995 Jul;6(4):347–353. doi: 10.1007/BF00051410. [DOI] [PubMed] [Google Scholar]
  21. Moore J. W., Key T. J., Bulbrook R. D., Clark G. M., Allen D. S., Wang D. Y., Pike M. C. Sex hormone binding globulin and risk factors for breast cancer in a population of normal women who had never used exogenous sex hormones. Br J Cancer. 1987 Nov;56(5):661–666. doi: 10.1038/bjc.1987.262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Nakao H. Birth seasonality of breast cancer patients and its variation according to menopausal status and histologic type in Japan. Eur J Cancer Clin Oncol. 1986 Sep;22(9):1105–1110. doi: 10.1016/0277-5379(86)90014-3. [DOI] [PubMed] [Google Scholar]
  23. Panagiotopoulou K., Katsouyanni K., Petridou E., Garas Y., Tzonou A., Trichopoulos D. Maternal age, parity, and pregnancy estrogens. Cancer Causes Control. 1990 Sep;1(2):119–124. doi: 10.1007/BF00053162. [DOI] [PubMed] [Google Scholar]
  24. Rogol A. D., Weltman A., Weltman J. Y., Seip R. L., Snead D. B., Levine S., Haskvitz E. M., Thompson D. L., Schurrer R., Dowling E. Durability of the reproductive axis in eumenorrheic women during 1 yr of endurance training. J Appl Physiol (1985) 1992 Apr;72(4):1571–1580. doi: 10.1152/jappl.1992.72.4.1571. [DOI] [PubMed] [Google Scholar]
  25. Rosenberg L., Metzger L. S., Palmer J. R. Alcohol consumption and risk of breast cancer: a review of the epidemiologic evidence. Epidemiol Rev. 1993;15(1):133–144. doi: 10.1093/oxfordjournals.epirev.a036097. [DOI] [PubMed] [Google Scholar]
  26. Rothman K. J., MacMahon B., Lin T. M., Lowe C. R., Mirra A. P., Ravnihar B., Salber E. J., Trichopoulos D., Yuasa S. Maternal age and birth rank of women with breast cancer. J Natl Cancer Inst. 1980 Oct;65(4):719–722. doi: 10.1093/jnci/65.4.719. [DOI] [PubMed] [Google Scholar]
  27. Teruel M., Bolufer P., Rodriguez A., Antonio P., Salabert M. T. Plasma sex steroids and SHBG in patients with breast cancer and their relation to tumor oestrogen-dependency. Exp Clin Endocrinol. 1989 Apr;93(1):37–44. doi: 10.1055/s-0029-1210834. [DOI] [PubMed] [Google Scholar]
  28. Toniolo P. G., Levitz M., Zeleniuch-Jacquotte A., Banerjee S., Koenig K. L., Shore R. E., Strax P., Pasternack B. S. A prospective study of endogenous estrogens and breast cancer in postmenopausal women. J Natl Cancer Inst. 1995 Feb 1;87(3):190–197. doi: 10.1093/jnci/87.3.190. [DOI] [PubMed] [Google Scholar]
  29. Trichopoulos D. Hypothesis: does breast cancer originate in utero? Lancet. 1990 Apr 21;335(8695):939–940. doi: 10.1016/0140-6736(90)91000-z. [DOI] [PubMed] [Google Scholar]
  30. Whelan E. A., Sandler D. P., Root J. L., Smith K. R., Weinberg C. R. Menstrual cycle patterns and risk of breast cancer. Am J Epidemiol. 1994 Dec 15;140(12):1081–1090. doi: 10.1093/oxfordjournals.aje.a117208. [DOI] [PubMed] [Google Scholar]
  31. Yanagibori R., Aoki K., Suzuki Y., Gunji A. [Evaluation of methods for measuring daily physical activity in terms of energy expenditure]. Nihon Koshu Eisei Zasshi. 1991 Jul;38(7):483–491. [PubMed] [Google Scholar]
  32. Yuen J., Ekbom A., Trichopoulos D., Hsieh C. C., Adami H. O. Season of birth and breast cancer risk in Sweden. Br J Cancer. 1994 Sep;70(3):564–568. doi: 10.1038/bjc.1994.346. [DOI] [PMC free article] [PubMed] [Google Scholar]

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