Table 2.

L. major Friedlin protein-coding gene families.

Family size*	Gene product(s)	L. major–specific	Organization†	Chromosome(s)
491	Hypothetical proteins (several annotations)	Some	D	Multiple
189	Kinesins/hypothetical proteins	Some	T+D	Multiple
60	Protein kinases (several groups)	Some	T+D	Multiple
46	Amastins	Most	T+TI+D	8, 31, 34, 36
32	Protein kinases (CMGC group)	One	D	Multiple
32	PSA-2 (GP46)	All	T+D	12, 21, 31, 35
29	RNA helicases/eIF-4a	None	T+D	Multiple
27	ATPase/serine peptidases	None	D	Multiple
29	Hypothetical proteins (kinesin-like)	One	D	Multiple
25	Protein phosphatases	None	T+D	Multiple
25	Tuzins	Some	TI+D	8, 34, 36
24	Protein kinases (STE group)	Some	D	Multiple
23	Amino acid permeases	Some	T+D	Multiple
19	HSP83	None	T+D	29, 33
18	DNA helicases	Some	D	Multiple
18	β-tubulins	None	T+D	8, 21, 33
17	Hypothetical proteins (LACK)	One	D	Multiple
17	Hypothetical proteins	Some	T+D	11, 13, 21, 29, 31, 36
15	Calpain-like cysteine peptidases	Some	T+D	4, 20, 25, 31, 36
14	HSP70 and related proteins	None	T+D	1, 18, 26, 28, 30, 35
14	Phosphoglycan β 1,3 galactosyltransferases	Some	T+D	2, 7, 14, 21, 25, 31, 35, 36
14	Dynein heavy chain	One	D	Multiple
14	RNA helicases	None	D	Multiple
14	α,γ,ε-tubulins	Bone	T+D	13, 21, 25
13	Hypothetical proteins (PIPK-like protein)	One	D	Multiple
13	Pteridine transporters	Some	T+D	4, 6, 10, 19, 35
13	Microtubule-associated proteins	All	T	9
13	ABC transporters/P-glycoproteins	Some	T+D	23, 25, 26, 31, 32, 33, 34
12	Protein kinases (NEK group)	One	D	Multiple
12	DNAJ chaperones	Some	D	Multiple
12	Hypothetical proteins	None	T+D	12
11	Long-chain fatty acid CoA ligases	Some	T+D	1, 13, 19, 28
11	Protein kinases (DYRK and CLK families)	One	D	Multiple
11	Translation elongation factors	None	T+D	11, 17, 18, 34, 35
10	Cyclophilins	None	D	Multiple
10	ABC transporters	Some	T+D	2, 11, 15, 27, 29
10	ATPases	None	T+D	4, 7, 17, 18, 33, 35
10	Clan CA, family C1 cysteine peptidases	Some	T+D	8, 19, 29
10	Hypothetical proteins (possible peptidases)	None	T+D	15, 16, 27

^*Families correspond to Tribe-MCL clusters (table S2) obtained using inflation value 4, and BlastP cut-off of e⁻¹⁵. Under these conditions, more divergent, but nonetheless functionally related proteins, may not get classified into a given gene family.

^†Tandem (T), tandem interspersed (TI), distributed (D).