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COX-dependent DA closure in neonatal mice. The DA was analyzed in pups 5 h after birth. (A) COX-1(+/+)/COX-2(+/+). (B) COX-1(−/−)/COX-2(−/−). (C) COX-1(+/−)/COX-2(−/−). (D) COX-1(+/−)/COX-2(−/−). (E) COX-1(+/−)/COX-2(−/−). (F) COX-1(−/−)/COX-2(+/−). Ao, aorta. (Scale bar, 100 μm.) Genotype figure labels, Ptgs1 genotype/Ptgs2 genotype.
