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COX-2-dependent DA closure after maternal indomethacin treatment. Histological sections are from fetal DA on gestation day 18.5. (A) COX-1(+/+)/COX-2(+/+). (B) COX-1(+/−)/COX-2(+/−). (C) COX-1(−/−)/COX-2(+/−). (D) COX-1(+/+)/COX-2(−/−). (E) COX-1(+/−)/COX-2(−/−). (F) COX-1(−/−)/COX-2(−/−). Ao, aorta. (Scale bar, 100 μm.) Genotype figure labels, Ptgs1 genotype/Ptgs2 genotype.
