Table 1.
Maternal genotype: | COX-1(+/−)/COX-2(+/−) | COX-1(−/−)/COX-2(+/−) | ||
---|---|---|---|---|
Paternal genotype: | COX-1(−/−)/COX-2(+/−)
|
COX-1(−/−)/COX-2(+/−)
|
||
Offspring genotype | Expected ratio | Obtained ratio* | Expected ratio | Obtained ratio† |
COX-1(+/−)/COX-2(+/+) | 0.125 | 0.110 | NA | NA |
COX-1(+/−)/COX-2(+/−) | 0.250 | 0.253 | NA | NA |
COX-1(+/−)/COX-2(−/−) | 0.125 | 0.115 | NA | NA |
COX-1(−/−)/COX-2(+/+) | 0.125 | 0.133 | 0.250 | 0.241 |
COX-1(−/−)/COX-2(+/−) | 0.250 | 0.293 | 0.500 | 0.474 |
COX-1(−/−)/COX-2(−/−) | 0.125 | 0.110 | 0.250 | 0.285 |
Litters were delivered after a normal gestation length of 19.5 days. Expected ratios are the Mendelian expectations. All obtained ratios are not significantly different from expected ratios (χ2 statistic, P < 0.01).
269 mice analyzed.
341 mice analyzed. NA, not applicable.