Figure 3.

(Left) AML+8 samples exhibit higher expression for genes on chromosome 8 than do AML-CN samples. The average expression levels for genes by chromosome in AML+8 relative to AML-CN are shown. (Right) The increased expression of genes on chromosome 8 as a function of chromosomal location. Of the 169 genes with a specific localization on the integrated radiation hybrid map of chromosome 8, 42 were expressed in a majority of AML samples. For these, the intensities in the AML+8 group are expressed as a percentage of the intensities in the AML-CN group. For comparison, the results for chromosome 1, which shows no gene dosage effect, are presented in the Inset.