TABLE 2.
Susceptibility to antibiotics of E. coli lacking an efflux pump
| E. coli strain or characteristic | MIC (μg/ml)a
|
|||
|---|---|---|---|---|
| CIP | CHL | TET | CO-TRIM | |
| CLSI recommended breakpoint concn | 4 | 32 | 16 | 4/16 |
| BSAC recommended breakpoint concn | 8 | 16 | 2 | 4 |
| Wild-type strain W3110 | 0.015 | 8 | 1 | >32 |
| tolC::kan | 0.0025 | 1 | 0.12 | 1 |
| acrAB::kan | 0.0025 | 1 | 0.12 | 16 |
| acrD::kan | 0.015 | 8 | 1 | >32 |
| acrEF::kan | 0.0025 | 1 | 1 | >32 |
a
CIP, ciprofloxacin; CHL, chloramphenicol; TET, tetracycline; CO-TRIM, cotrimoxazole. Data extracted from Sulavik et al. (215). (Note that values have been rounded to typical doubling dilutions for ease of comparison between tables.)