TABLE 7.
Susceptibility to antimicrobial agents of S. aureus overexpressing norA
| S. aureus strain or characteristic | MIC (μg/ml)a
|
|||
|---|---|---|---|---|
| NOR | CIP | NAF | VANC | |
| CLSI recommended breakpoint concn | 16 | 4 | 4 | 32 |
| BSAC recommended breakpoint concn | 2 | 8 | ||
| SA-1199 | 0.5 | 0.5 | 0.5 | 0.5 |
| SA-1199Bb | 64 | 16 | 0.5 | 0.5 |
| SA-1199-3c | 16 | 4 | 0.5 | 0.5 |
a
NOR, norfloxacin; CIP, ciprofloxacin; NAF, nafcillin; VANC, vancomycin. Data are from Kaatz and Seo (73) and Kaatz (personal communication).
b
Possesses a mutation in grlA and overexpresses norA.
c
Inducible overexpression of norA.