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Four Sequential Questions that Have Hallmarked Progress in the Development of Human Cancer Immunotherapy
| 1. Is it possible? (Can immune stimulation cause the regression of established human cancers?) |
| 2. What are the antigens involved? |
| 3. Can antitumor T-cells be generated in vivo by antigen immunization? |
| 4. What mechanisms limit cancer regression despite the in vivo generation of antitumor T-cells? |
