Table 5.
Class I Restricted Melanoma Antigens Recognized by Tumor Infiltrating Lymphocytes
| Name of antigen | Tumor infiltrating lymphocytes used for identification | HLA restriction | Immunodominant epitopes | Characteristics |
|---|---|---|---|---|
| MART-1 | 1235 and others | A2 | AAGIGILTV | Normal differentiation antigen |
| gp100 | 1200 and others | A2 | KTWGQYWQV | Normal differentiation antigen |
| ITDQVPFSV | – | |||
| YLEPGPVTA | – | |||
| 1351 | A3 | LIYRRRLMK | – | |
| 888 | A24 | VYFFLPDHL | Intronic sequence | |
| Tyrosinase | 888&1413 | A24 | AFLPWHRLF | Normal differentiation antigen |
| 1388 | A1 | SSDYVIPIGTY | – | |
| 1138 | A2 | YMDGTMSQV | – | |
| p15 | 1290 | A24 | AYGLDFYIL | Posttranscriptional control |
| b-catenin | 1290 | A24 | SYLDSGIHF | Single base mutation |
| TRP-1 | 586 | A31 | MSLQRQFLR | Translated from alternative open reading frame |
| TRP-2 | 586 | A31 | LLGPGRPYR | Normal differentiation antigen |
| 1790 | A2 | SVYDFFVWL | – | |
| MART-2 | TIL 1362 | A1 | FLEGNEVGKTY | Mutation in phosphate binding loop;loss of ability to bind GTP |
| AIM-1 | MLT 1300-C22 | A2 | AMFGREFCYA | Normal differentiation antigen;isolated using immunoselected tumor |
| AIM-2MLT | 1300-C9 | A1 | RSDSGQQARY | Shared on neuroectodermal tumors (neuroblastoma, Ewing’s sarcoma) |