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Breakthrough of NNRTI-resistant HIV-1 in UC781-pretreated cells subsequently exposed to HIV-1 in the absence of exogenous drug
| Virus mixture (ratio) | No. of clones analyzed | No. (%) of NNRTI-resistant HIV-1 strains/no. tested in breakthrough population |
|---|---|---|
| No UC781 pretreatment | ||
| wt/UCR (50:50) | 12 | 6/12 (50) |
| wt/UCR (90:10) | 30 | 2/30 (7) |
| wt/EFVR (50:50) | 30 | 15/30 (50) |
| Cells pretreated with 25 μM UC781 | ||
| wt/UCR (50:50) | 13 | 12/13 (92) |
| wt/UCR (90:10) | 31 | 22/31 (71) |
| wt/EFVR (50:50) | 30 | 26/30 (87) |
