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A schematic diagram depicting the signaling pathway for TNF-α-mediated apoptotic cell death and the inhibitory role of HCV core protein. TNFR1 associates with TRADD, which recruits FADD for activation of caspase-8, and initiates the apoptotic signaling pathway. HCV core protein appears to inhibit TNF-α-mediated apoptosis by sustained c-FLIP expression, thus impairing activation of caspase-8 for downstream signaling of executioner caspases.
