TABLE 2.
Summary of clinical signs and virus isolation from the brain segments
| Virus | Animal no. | Neurological signsb | Virus isolation
|
|||
|---|---|---|---|---|---|---|
| PFU (range) | Scorec (no. of rabbits)
|
|||||
| Nose 3 dpi | Olfactory bulb | Anterior cortex | Posterior cortex | |||
| BHV-5 Us9-1a | 17 | Severe (12) | 500 (150-1,150) | ++ (6) | +++ (6) | +++ (6) |
| BHV-5 wild type | 5 | Severe (3) | 950 | ++ (2) | +++ (2) | +++ (2) |
| BHV-5 Us9Δ | 5 | None | 600 | − | − | − |
a
Data collected from two independent experiments.
b
Numbers in parentheses indicate number of animals showing clinical signs or brain segments positive for virus isolation.
c
−, no virus detected; ++, 100 to 990 PFU/g; +++, 1,000 to 10,000 PFU/g.