TABLE 1.
Changes in transcription factor binding to HPV-16 promoters during cellular differentiation
| Transcription factor | Fold increasea or decrease |
|---|---|
| Increased binding during differentiation | |
| AP-2 | 6.39 |
| ATF2 | 100 |
| C/EBPα | 7.61 |
| CACC | 100 |
| CBF/NF-Y | 100 |
| C-Myb | 100 |
| CP1 | 100 |
| CPIB | 100 |
| EBP40, -45 | 10.1 |
| ETF | 100 |
| GAG | 5.87 |
| GBF1, -2, -3, HY5 | 100 |
| GKLF | 3.03 |
| H4TF-1 | 100 |
| HIF-1 | 51.4 |
| KTP | 100 |
| Lactoferrin BP | 100 |
| LCR-F1 | 100 |
| MT-box | 5.75 |
| MTF | 100 |
| NF1 | 100 |
| NFAtx | 100 |
| NF-kB | 3.83 |
| Pax5 | 100 |
| PCF | 2.03 |
| PEBP | 100 |
| RFX1, 2, 3 | 20.3 |
| RIPE3a | 100 |
| RORE | 2.56 |
| Snail | 100 |
| Stat5 | 3.83 |
| TFE3L | 100 |
| WT1 | 25.3 |
| YY1 | 2.38 |
| Decreased binding during differentiation | |
| AP-1 | 2.93 |
| GRE | 14.6 |
| MyoG | 6.76 |
| Pbx1 | 2.04 |
| TREF1, -2 | 33.0 |
a
When a TF was absent in undifferentiated cells but present upon differentiation, an infinity value was assigned for the fold increase by the software. The infinity value has been arbitrarily assigned a value of 100.